报告题目：Regulating antibody response by follicular helper T cells
CD4 T cells play a central role in regulating the immune system. Regulatory functions of CD4 T cells are specified by their commitment into different subsets, including Th1, Th2, Th17, Tfh and Treg cells as major subsets. We are studying a newly identified specialised helper T cell subset, termed follicular helper T (Tfh) cells, which is essential to regulate the high-affinity and long term antibody responses. Antibodies are the basis of most successful vaccinations. Diminished antibody responses lead to immunodeficiency while excessive antibody responses contribute to autoimmune diseases. In last few years, we have identified the key transcription factor Bcl6 directing the differentiation of Tfh cells and demonstrated excessive Tfh cells promoting autoimmunity using animal models. Understanding CD4 T cell subsets pave the way for immunomonitoring and immunomodulation in disease diagnosis and treatment.