杜昱光 研究员
  • 学历/学位: 研究生学历/博士学位
  • 研究方向: 糖生物工程、营养糖生物学
  • 邮箱: ygdu@ipe.ac.cn
  • 地址: 北京市海淀区中关村北二街1号
  • 邮编: 100190

简历介绍

杜昱光研究员,中国科学院过程工程研究所生化工程国家重点实验室糖生物工程课题组组长,生物剂型与生物材料研究部副主任,国家生化工程技术研究中心(北京)副主任,兼任中国生物工程学会常务理事,中国生物工程学会糖生物工程专业委员会主任委员。目前已主持及参加省部级以上科研项目五十余项;杜昱光研究员团队先后在国内外刊物上发表论文240余篇;撰写中英文论著6本;申请发明专利百余项,授权发明专利40余项;获省部级科技进步一等及二等奖共5项。培养硕士、博士研究生50余人,合作博士后9人。

研究方向:以营养糖生物学及糖工程研究为基础,建立天然寡糖库、糖苷酶库、微流控芯片器官及寡糖活性功能筛选平台,开发功能糖制备新技术及研发系列功能糖产品,应用于健康养殖、绿色种植、功能食品及先导化合物药物研发;基于数字芯片技术等流控芯片新技术,研发快速、灵敏、高通量便携式现场核酸等检测设备及系列试剂盒产品;构建基于肿瘤及血管细胞的肿瘤迁移、侵袭器官芯片,可周期蠕动、肠道菌与人体细胞共培养的仿生层叠式大肠器官芯片,以及模拟血管糖萼生理病理变化的血管芯片。

代表论著

1.Junping Zheng,Xubing Yuan,Gong Cheng,Siming Jiao,Cui Feng,Xiaoming Zhao,Heng Yin,Yuguang Du, Hongtao Liu. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice, Carbohydrate Polymers, 2018, 190:77-86. 
2.Jinhua Wei, Zhuo A. Wang,Bing Wang , Marefa Jahan, Zhongfu Wang, Peter C. Wynn & Yuguang Du. Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs, Scientific reports, 2018, 8: 4688-4704. 
3.Chen Zhang,Siming Jiao, Zhuo A. Wang and Yuguang Du . Exploring Effects of Chitosan Oligosaccharides on Mice Gut Microbiota in in vitro Fermentation and Animal Model, Frontiers in Microbiology, 2018,9: 2388-2399. 
4.Guiqiang Zhang,Jing Liu , Ruilian Li, Siming Jiao, Cui Feng, Zhuo A. Wang and Yuguang Du. Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan, Mar. Drugs, 2018, 16:151-164. 
5.Junping Zheng,Gong Cheng, Qiongyu Li,Siming Jiao , Cui Feng , Xiaoming Zhao,Heng Yin, Yuguang Du  and Hongtao Liu. Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice, Mar. Drugs, 2018, 16:66-83. (IF 4.186)
6.Yibo Bai,Junping Zheng,Xubing Yuan,Siming Jiao,Cui Feng,Yuguang Du ,Hongtao Liu and Lanyan Zheng. Chitosan Oligosaccharides Improve Glucolipid Metabolism Disorder in Liver by Suppression of Obesity-Related Inflammation and Restoration of Peroxisome Proliferator-Activated Receptor Gamma (PPAR), Mar. Drugs, 2018, 16:455-470. 
7.Qingsong Xu,Chen Qu, Jin Wan,  Gong Cheng, Wen Yang, Changhao Gong, Jun He and Yuguang Du. Effect of dietary chitosan oligosaccharide supplementation on the pig ovary transcriptome, RSC Advances, 2018, 8: 13266-13273. 
8. Pengfei Zhang,Xianghua Yuan, Yuguang Du and Jian-Jun Li. Heterologous expression and biochemical characterization of a GHF9 endoglucanase from the termite Reticulitermes speratus in Pichia pastoris, BMC Biotechnology, 2018, 18(1):35-44. 
9.Xianghua Yuan,Pengfei Zhang, Siming Jiao,Yuguang Du,Jian-Jun Li. Overexpression and biochemical characterization of a recombinant psychrophilic endocellulase from Pseudoalteromonas sp. DY3, International Journal of Biological Macromolecules, 2018, 116:100-105.