张欣 研究员
  • 学历/学位: 研究生学历/博士学位
  • 研究方向: 基因药物剂型工程
  • 邮箱: xzhang@ipe.ac.cn
  • 地址: 北京市海淀区中关村北二街1号
  • 邮编: 100190

简历介绍

国家优秀青年科学基金获得者,现任生化工程国家重点实验室副主任。于天津大学获得学士和硕士学位、法国斯特拉斯堡大学获得博士学位。回国后建立“基因药物剂型工程”课题组,长期聚焦制约基因治疗/核酸疫苗成败的瓶颈等前沿和关键科学问题,通过生物材料分子的理性设计,发现了生物材料分子结构与功能随微环境变化的特征,论证了对基因药物成药/核酸疫苗免疫过程进行调控的可能性和机制,建立了具有自己特色的基因药物/核酸疫苗输递的研究方向。任Theranostics和Bioactive Materials编委、中国生物物理学会纳米生物学分会理事、中国生物材料学会青年委员会委员等。获得中国生物材料学会“青年科学家奖”,被Nano Research期刊授予“2018 Young Innovator Award in Nanobiotechnology”,获得省部级科学技术一等奖。

代表论著

1.Yan Li#, Linying Liu#, Weihong Ji#, Huan Peng, Ruichen Zhao, Xin Zhang*. Strategies and Materials of “SMART” Non-Viral vectors: Overcoming the Barriers for Brain Gene Therapy. Nano Today, 2020, 35, 101006-101028. (IF=16.907) 
2.Ruiyuan Liu#, Jun Yang#, Linying Liu, Zhiguo Lu, Zhuyan Shi, Weihong Ji, Jie Shen, Xin Zhang*. An ‘Amyloid-β Cleaner’ for the Treatment of Alzheimer’s Disease by Normalizing Microglial Dysfunction. Advanced Science, 2020, 7, 1901555-1901567. (IF=15.840)  
3.Linying Liu#,Yan Li#, Huan Peng, Ruiyuan Liu, Weihong Ji, Zhuyan Shi, Jie Shen, Guanghui Ma, Xin Zhang*.Targeted Exosome Coating Gene-Chem Nanocomplex as “Nanoscavenger” for Clearing α-synuclein and Immune Activation of Parkinson’s Disease. Science Advances, 2020, 6, eaba3967-eaba3978. (IF=13.116)  
4.Linying Liu#, Yan Li#, Ruiyuan Liu, Qi Shen, Yanhui Li, Zhuyan Shi, Jie Shen, Weihong Ji, Xin Zhang*. Switchable Nanoparticle for Programmed Gene-chem Delivery with Enhanced Neuronal Recovery and CT Imaging for Neurodegenerative Disease Treatment. Materials Horizons, 2019, 6, 1923-1929. (IF=12.319)  
5.Qi Shen#, Jun Yang#, Ruiyuan Liu, Linying Liu, Jinchao Zhang, Shigang Shen*, Xin Zhang*. Hybrid ‘clusterbombs’ as multifunctional nanoplatforms potentiate brain tumor immunotherapy. Materials Horizons, 2019, 6, 810-816. (IF=12.319) 
6.Chenmeng Qiao#, Jun Yang#, Qi Shen, Ruiyuan Liu, Yanhui Li, Yuanjie Shi, Jingli Chen, Yanqin Shen, Zuobing Xiao, Jie Weng*, Xin Zhang*, Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment, Advanced Materials, 2018, 30, 1705054-1705063. (IF=27.398)  
7.Yan Li, Yanhui Li, Weihong Ji, Zhiguo Lu, Linying Liu, Yuanjie Shi, Guanghui Ma, Xin Zhang*. Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy. JACS, 2018, 140, 4164?4171. (IF=14.612) 
8.Zhiguo Lu#, Yan Li#, Yuanjie Shi, Yanhui Li, Zuobing Xiao, Xin Zhang*.Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for 5 Synergistic Glioblastoma Multiforme Treatment. Advanced Functional Materials, 2017, 27, 1703967-1703980. (IF=16.836)  
9.Ran Zhang#, Yan Li#, Bingbing Hu, Zhiguo Lu, Jinchao Zhang*, Xin Zhang*. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy. Advanced Materials, 2016, 28, 6345-6352. (IF=27.398) ? Heng Deng#, Fengying Dai#, Guanghui Ma, Xin Zhang*. Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance. Advanced Materials, 2015, 27, 3645-3653. (IF=27.398)  
10.Binging Hu#, Fengying Dai#, Zhanming Fan, Guanghui Ma, Qunwei Tang*, Xin Zhang*. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimers Disease in APPswe/PS1dE9 Transgenic Mice. Advanced Materials, 2015, 27, 5499-5505. (IF=27.398)